منابع مشابه
DFT calculations on quetiapine hemifumarate as a pharmaceutical compound for the treatment of schizophrenia
In this work, the optimization calculations were carried out on quetiapine hemifumarat, 4, and its analogues, 1-5. These calculations were carried out using the B3LYP/6-31G(d) level of theory. The DFT calculations clarified a boat structure for dibenzothiazepine moiety of the molecule which piperazine moiety has a chair conformation. Thermal energies (E), enthalpies (H), and free energies (G) o...
متن کاملQuetiapine Therapy in Treatment-Refractory Schizophrenia
Objective: We investigated the effects of an atypical antipsychotic agent, quetiapine, in treatment-refractory schizophrenia. Methods: The subjects were 10 inpatients who were diagnosed according to the DSM-IV criteria for schizophrenia. They were termed treatment refractory. We tried to switch patients from typical antipsychotics to quetiapine. Each patient gave informed consent for the resear...
متن کاملdft calculations on quetiapine hemifumarate as a pharmaceutical compound for the treatment of schizophrenia
in this work, the optimization calculations were carried out on quetiapine hemifumarat, 4, and its analogues, 1-5. these calculations were carried out using the b3lyp/6-31g(d) level of theory. the dft calculations clarified a boat structure for dibenzothiazepine moiety of the molecule which piperazine moiety has a chair conformation. thermal energies (e), enthalpies (h), and free energies (g) o...
متن کاملQuetiapine in the treatment of schizophrenia and related disorders
Quetiapine was developed in 1985 by scientists at AstraZeneca (formerly Zeneca) Pharmaceuticals. It received official US Food and Drug Administration approval in September 1997 and approval in Germany in 2000. Since then, quetiapine has been used in the treatment of severe mental illness in approximately 70 countries including Canada, most Western European countries, and Japan. Quetiapine is a ...
متن کاملThe management of schizophrenia: focus on extended-release quetiapine fumarate
Effective management of schizophrenia remains a significant clinical challenge. While antipsychotic medications have proven efficacy in this disease, there remains an opportunity to further improve symptom control and long-term relapse prevention. Also, a number of factors, including tolerability and complex dosing regimens, can result in nonadherence to medication. Quetiapine is an atypical an...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2004
ISSN: 1465-1858
DOI: 10.1002/14651858.cd000967.pub2